The need for cost-effective choices to treat patients with bipolar 1 disorders including asenapine

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The need for cost-effective choices to treat patients with bipolar 1 disorders including asenapine.

BACKGROUND Bipolar 1 disorders (BPD) are a chronic disorder with prevalence rates of up to 2.6% of the adult population or higher and appreciable direct and indirect costs. As a result, these are a concern to health authorities especially given the low age of onset. Consequently, there is a need to treat BPD patients well and improve their quality-of-life. Pharmacotherapy includes mood stabiliz...

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Asenapine for bipolar disorder

Asenapine (Saphris(®)) is an atypical antipsychotic drug which has been approved by the US Food and Drug Administration for the treatment of schizophrenia in adults, as well as the treatment of acute manic or mixed episodes of bipolar I in both adult and pediatric populations. Asenapine is a tetracyclic drug with antidopaminergic and antiserotonergic activity with a unique sublingual route of a...

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Cost-effectiveness of asenapine in the treatment of bipolar I disorder patients with mixed episodes.

OBJECTIVE Around one-third of patients with bipolar I disorder (BD-I) experience mixed episodes, characterized by both mania and depression, which tend to be more difficult and costly to treat. Atypical antipsychotics are recommended for the treatment of mixed episodes, although evidence of their efficacy, tolerability, and cost in these patients is limited. This study evaluates, from a UK Nati...

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Asenapine augmentation in bipolar disorders: a case series

Asenapine, a novel second-generation antipsychotic is effective in acute treatment of bipolar I disorder patients in combination with mood stabilizers even in resistant cases. Although there is no evidence for asenapine's efficacy to be superior to currently available agents, asenapine's favorable weight and metabolic profile are of clinical interest.

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Asenapine for Bipolar Disorder in Older Adults

Methods: Participants, aged ≥60 years, were experiencing suboptimal response—defined as irritability, agitation, and mood lability or diminished ability to take care of basic personal needs as a result of their illness—to their current bipolar disorder medication. All patients had open-label, flexible-dose, sublingual asenapine added to their current medication for 12 weeks. Responses were eval...

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ژورنال

عنوان ژورنال: Journal of Medical Economics

سال: 2015

ISSN: 1369-6998,1941-837X

DOI: 10.3111/13696998.2015.1073736